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Description
Clinical application of cisplatin (CP), a widely prescribed drug in cancer chemotherapy, is sometimes associated with undesirable side effects, particularly in the gastrointestinal tract [195]
This led us to hypothesize that inactivating the relevant repair pathway would lead to an increase in mutation and potentially allow us to better characterize the endogenous DNA lesions
Mastoparan is a novel inhibitor of this activation pathway and may help identify molecular participants in TGF-1 regulation
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