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J Bioenerg Biomembranes (2002) 34:397406

91 Another subsequent network meta-analysis that also included upadacitinib, filgotinib, and ozanimod concluded that upadacitinib was the most efficacious first-line induction therapy for both induction and maintenance therapy in bio-naive patients

Mechanistically, current studies have found that radiation promotes the release of free iron through multiple pathways, including impairing the storage capacity of ferritin by reducing iron oxides [66], causing the release of intracellular free iron by promoting hydrolysis of ferritin proteins [67] and inducing bone marrow hemorrhage [68]

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