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Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium

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113,114,116,117 The net result of these events is that apoptosis is inhibited through reduced expression of pro-apoptopic nuclear factor-B and Bcl-2-like protein 4 and increased expression of the anti-apoptopic molecules B-cell lymphoma 2, B-cell lymphoma extra-large and X-linked inhibitor of apoptosis protein