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doi: 10.1016/j.bbamcr.2016.01.023 12 PlacidiMEmidioGDVirmaniAD'AlfonsoAArtinPGD'AlessandroAMet al
Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria

Lactate and pyruvate are transported by monocarboxylate transporters (MCTs) and mitochondrial pyruvate carriers (MPCs) in the cell membrane and mitochondrial membrane

It is more common if a relative has it and if you have scleroderma
