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In functional medicine, where holistic approaches to health are embraced, the spotlight often falls on the remarkable potential of vitamins and minerals to support wellness

Core clock genes control the circadian rhythm in the suprachiasmatic nucleus (SCN), the master central pacemaker in the hypothalamus (56)

Specifically, the malate/aspartate shuttle proteins MDH2, -KG/malate carrier, and GOT2 were found to be hyperacetylated leading to suppression of the transport and oxidation of cytosolic NADH in mitochondria, which correlated with decreases in oxygen consumption and cardiac energetics (manifested by a reduction in phosphocreatine/ATP) (42, 47)

doi: 10.1016/j.ijrobp.2010.12.070 166 YaharaKOhguriTUdonoHYamamotoJTomuraKOnodaTet al