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Complementing immune regulation, Clostridium rebalances gut microbiota homeostasis by enriching beneficial taxa and inhibiting pro-inflammatory bacterial overgrowth and reinforces intestinal barrier integrity by upregulating tight-junction proteins and mucin secretion, thereby blocking the translocation of pathogens and antigens that initiate systemic autoimmunity

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In addition, a study has revealed that overexpression of miR429 inhibits the NF-B signaling pathway by targeting programmed cell death 4 (PDCD4) to reduce apoptosis and improve cell viability in a CI-AKI cell model (Niu et al., 2021)