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Furthermore, BTZ treatment in rats caused a decrease in SIRT1 levels, which subsequently reduced STAT3-mediated histone hyperacetylation in the neutrophilic alkaline phosphatase 1 promoter region of dorsal horn neurons, ultimately contributing to the development of mechanical pain hypersensitivity (Chen et al., 2018)

The funding institutions had no role in the study design, data collection and analysis, or in writing the manuscript

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