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-carotene, a precursor of retinol and retinoic acid, is reported to be a potent free radical quencher, singlet oxygen scavenger, and lipid antioxidant in tissues and plasma

Statements Author contributions JL: Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Writing original draft, Writing review & editing

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If a drug is taken into the gastrointestinal tract (GI tract), where it enters the hepatic portal system through the portal vein, it becomes well-metabolized and is said to show the first pass effect