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This meant that it would be necessary to duplicate the in vitro assays based on human receptors in a rat version also

doi: 10.1038/s41598-017-15571-7

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In addition, DPP-4 modulates multiple substrates such as GLP-1, BNP, substance P, and neuropeptide Y (NPY), leading to potential extra-pancreatic effects, particularly the promotion of sodium excretion in urine (186)
