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This drop can be largely explained by 1) the overactivation of IDO-1 shunts the available TRYP into KP, increasing KP metabolites, depleting serotonin, and causing mood disorders and other related neurological symptoms

[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Sultana R., Perluigi M., Butterfield D.A

Furthermore, CHAC2 appears to negatively influence CHAC1-mediated GSH degradation, suggesting a direct competitive interaction (Wang et al., 2017)

Acta, 1782: 355-360
