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It is worthy to note that cardiovascular disease and kidney disease are closely interrelated [80] and diminished renal function is strongly associated with morbidity and mortality in heart failure patients [81]
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Hedia MG, El-Belely MS, Ismail ST, Abo El-Maaty AM
Additionally, the hypoxic microenvironment within tumors can induce the expression of HIF-1, which promotes EMT and activates survival pathways, thereby contributing to chemotherapy resistance (68)
