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[ 38 ] In contrast, antioxidants, such as vitamins C and E and Nacetylcysteine (NAC), prevent BACH1 degradation and inhibit the release of free heme by lowering ROS levels, [ 39 ] since ROS stimulates free heme release through the oxidization of hemecontaining proteins

Multiple transcriptomic and immunohistochemical studies have reported that elevated expression of core necroptosis regulators (RIPK3 and MLKL) or composite necroptosis gene signatures correlates with increased intratumorally CD8 + T-cell density and a T-cell-inflamed gene expression profile (20)
