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The condition involves dysregulation of neurotransmitters, inflammatory mediators, and stress response systems, producing a constellation of symptoms extending far beyond pain to include crushing fatigue, unrefreshing sleep, cognitive dysfunction known as fibro fog, and heightened sensitivity to temperature, sound, and light

Pasricha, P

In a small, randomized controlled trial in the American Journal of Psychiatry in which 52 women with major depressive disorder were assigned to receive escitalopram (Lexapro, a type of antidepressant medication) plus creatine monohydrate or escitalopram plus a placebo, those in the former group showed significantly greater improvements in their depression rating scores as early as the second week of treatment

On the gastrointestinal front, literature has described mucosal barrier protection via modulation of endogenous prostaglandin (PGE2) and heat shock proteins (HSP70/90)