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[PubMed 3087165] 1026

For example, a study demonstrated dosedependent nephrotoxicity from CuONPs in rabbits, showing elevated kidney biomarkers (blood urea nitrogen, uric acid, creatinine) and tissue damage (hyperaemia, inflammation) after 15day exposure, highlighting potential toxicity concerns in this regard (Yegeubayeva et al

M., Weinberg V., et al

Under these circumstances cortical hypoxia is overt, leading to activation of the renin-angiotensin-aldosterone system, loss of kidney function, rarefaction of small renal vessels, kidney fibrosis, atrophy, and end stage kidney disease designated ischemic nephropathy