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mTORC1 is often deregulated in multiple cancers and its activation promotes anaplerotic glutamine entry into the TCA cycle 48
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Several investigators describe a group of cats with LC where inflammation is confined to portal regions and there is a lack of targeting of bile ductules or biliary epithelium.2, 20, 21 This has been referred to as lymphocytic portal hepatitis .2, 21 The connection between this histopathologic finding and clinical disease in cats is unknown, as it may represent a common change associated with aging
