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It should be emphasized that during corticosteroid therapy prolonged for more than 2 weeks, there is a risk of developing adrenocortical insufficiency, which is manifested by the inhibition of ACTH secretion and adrenal atrophy

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Amyloid protein, on the other hand, is implicated in regulation of synaptic function, improving memory and protection of neurons from oxidative stress ( Probably the most significant form of amyloid related neuropathy is associated with -synuclein, a major neurosynaptic chaperone which mediates release of neurotransmitters (Sulzer and Edwards, 2019)