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Plasma levels of total GSH, free GSH, GSSG, and the ratio of free GSH to GSSG were then independently analyzed to produce 16 measures per animal

Oxidative Stress in the Pathogenesis of Disease Oxidative stress participates in the pathogenesis of diverse inflammatory and metabolic diseases across multiple organs, including musculoskeletal diseases, cardiac diseases, dermatological diseases, cancer, obesity, diabetes, and hypertension (Figure 4)

and accordingly nerve damage appeared in various brain areas, with most prominent damage in corpus callosum, laterodorsal thalamus, nucleus reunions, anterior horn motor neurons, regional heterogeneities which suggest differences in the underlying pathophysiology as it had been previously claimed (72)