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While this targeted approach may appeal to some, it does not always align with therapies designed to support long-term physiologic hormone patterns

doi: 10.16073/j.cnki.cjcpt.2013.07.020 58 ZimmermanCAthertonPJPachmanDSeislerDWagner-JohnstonNDakhilSet al

Chronic treatment with PARP inhibitors increased NAD + levels and mitochondrial respiration in 10-week-old mice and triggered UPR mt and increased mitochondrial respiration and lifespan in worms 109,257
