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Genetic variants do not determine treatment outcome but may inform personalization discussions

( As shown in Table B1 and in the CY 2023 HH PPS final rule (87 FR 66805), a permanent prospective adjustment of -6.52 percent to the CY 2023 30-day payment rate would be required to offset for such increases in estimated aggregate expenditures in future years

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Furthermore, the addition of vincristine does not significantly alter the proteomic profile linked to the activity of the other two compounds, while still causing more cell death when combined with MitoQ and DPI at a low dosage