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Low GSH in aging is associated with lower intake of GSH precursors, mainly cysteine, and lower GSH synthesis evidencing diminished function of nuclear factor erythroid 2related factor 2 (Nrf2)-dependent inductive mechanisms that enhance glutamate cysteine ligase expression, rate limiting factor for the synthesis of GSH (McCarty and DiNicolantonio, 2015)

[DOI] [PubMed] [Google Scholar] [126].Morgan B, Ezerina D, Amoako TN, Riemer J, Seedorf M, Dick TP, Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis, Nat

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When activated, these receptors trigger intracellular signaling cascades involving cAMP elevation, protein kinase A activation, and hormone-sensitive lipase stimulation, ultimately leading to triglyceride breakdown and fat mobilization