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Reduced NO bioavailability induces LSEC capillarization characterized by loss of the LSEC window pore and basement membrane formation and leads to an imbalance in its secretion of vasoactive substances, which contributes to MASLD progression

A multitude of investigations have elucidated the critical role of oxidative stress, mitochondrial dysfunction, and hepatocyte death in the mechanism of APAP overdose-induced liver diseases [110, 267,268,269,270]

In particular, BHB, in addition to its role as an energy source, also has a variety of molecular signaling and regulatory functions in a wide range of human diseases ( 4.1 Epigenetic regulation BHB has been reported as a Class I histone deacetylase (HDAC) inhibitor and an endogenous neuroprotective epigenetic modifier ( 4.2 Gut microbiome Gut microbes are also known to be involved in the development of many diseases