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8.2.3 Effects on skin and eye MC has irritative action on eye and skin

It also regulates blood pressure and cholesterol levels

Cytokines do not need to function as circulating endocrine molecules to drive subjective sickness symptoms because they can be detected by the sensitive and highly branched afferent vagus nerve, which communicates their presence to the brain via brainstem and triggers neuroinflammation and sickness responses ( do not have to be detectable in the periphery in order to have an effect on sickness-related symptoms
