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Abstract The purpose of this study was to investigate the utility of plasma pharmacokinetic and pharmacodynamic measures including plasma deoxynucleosides, homocysteine and methylmalonic acid concentrations in understanding the time course and extent of the inhibition of thymidylate synthase (TS) by pemetrexed in the context of a phase I/II combination study with vinorelbine

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Say the patient was going on holiday on the Monday, then why would giving the patient it a day early (from a day they are not open) be any strain on resources as the patient is not going to book another appointment on the Monday