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Current protocols are based on preclinical extrapolation, anecdotal clinical experience, or single-dose pharmacokinetic studies rather than on systematic dose-finding trials ( Third, the effects of combination therapy are unexplored
In contrast to the frontal association cortex, neurons in the auditory cortex, which is involved in fear memory recall, respond to fear conditioning by increased spinogenesis, and fear extinction favors the elimination of those new spines (Lai et al., 2018)

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Evaluation of D-Methionine (D-Met) in Acute Cisplatin Induced Hearing Loss (CIHL) Model FIG
