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Thus, there are several unanswered questions that need to be studied with extensive preclinical mechanistic studies to explore the specific roles of antioxidants with respect to types, forms and stages of brain tumors in order to achieve their clinical utility in brain cancer management

Think of oxidative stress as the "wear and tear" that happens at a cellular level due to environmental pollutants, processed foods, and the natural process of aging

Specifically, SIRT1, SIRT3, and SIRT5 protect the cell from ROS, and SIRT2, SIRT6, and SIRT7 modulate oxidative stress 138,139
