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Thus, we posit that the dose of APR-246 needed to sufficiently restore wildtype function and overcome dominant negative effects of remaining p53 mutants is the major limitation in these studies

coli to human remains pertinent

[DOI] [PMC free article] [PubMed] [Google Scholar] 19.Perovic D, Kolenc D, Bilic V, Somun N, Drmic D, Elabjer E, et al

The patients are recovering based on their physiological resistance when subjected to empirical treatments (Shin, 2020)