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PMID: 13678664
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Addition of hydrophobic methyl group substitutions around the quinolinium scaffold (previously shown to negatively impact NNMT inhibitory activity) only slightly improved membrane permeability via passive transport as indicated by the low, but non-zero, permeability values for 1,8-diMQ and 1,2,4,8-tetraMQ (Table 4)
135,136 The underlying mechanism is that these cells lacking IDH2 show enhanced invasive behavior due to the increase in matrix metalloproteases, which depend on the NF-B pathway
