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In contrast, novel microbial amino acid-conjugated BAs (e.g., Trp-CDCA), identified through reverse metabolomics, robustly enhanced IFN- production in CD4 + T cell assays, suggesting a Th1-promoting role for select microbial BA metabolites that contrasts with LCAs inhibitory effects (82)

The desired result of this resting state of the insulin biosynthesis apparatus can be ideally a cessation of proinsulin folding and thus a reduction of H 2 O 2 generation, thereby reducing the ER stress

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