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Reconstitute pemetrexed for injection to achieve a concentration of 25 mg/mL as follows: Reconstitute each 100-mg vial with 4.2 mL of 0.9% Sodium Chloride Injection, USP (preservative-free) Reconstitute each 500-mg vial with 20 mL of 0.9% Sodium Chloride Injection, USP (preservative-free) Reconstitute each 1,000-mg vial with 40 mL of 0.9% Sodium Chloride Injection, USP (preservative-free) Do not use calcium-containing solutions for reconstitution

Maximum effects occur by week 8 to 12

Women who become pregnant while receiving HCG should discontinue its use immediately and consult their physician

[PubMed] pubmed.ncbi.nlm.nih.gov DeLoughery TG