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A research project of Professor Graham has been supported by GlaxoSmithKline and Professor Day is a member of advisory boards for the companies marketing celecoxib (Pfizer and Pharmacia), rofecoxib (Merck) and paracetamol (acetaminophen) [GlaxoSmithKline]

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505 After invading the subcutaneous tissue, the bacteria proliferate and release exotoxins, which induce platelet-leukocyte aggregation, block capillaries, and damage the vascular endothelium, leading to fluid leakage, tissue swelling, and erythema