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192 While DNA damage often leads to genomic instability and tumorigenesis, damage at the telomeres can promote cell death
Therefore, understanding the spatiotemporal dynamics of ROS in physiological and pathological settings is crucial for developing targeted intervention strategies
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These two cycles are linked by methionine synthase (MS), the rate-limiting enzyme in one-carbon metabolism that converts homocysteine (Hcy) to methionine (Met) using 5-methyltetrahydrofolate (5-mTHF) as a methyl donor and B12 as an essential cofactor [8,17]
