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If the patient has heart failure, the nonrenal (hepatic) clearance might be halved because of hepatic congestion and hypoxia, so the expected clearance would become 5.5 L/h
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The liver safety issues with the Pfizer compounds were related to their specific chemical structures rather than being a class effect of all small-molecule GLP-1 agonists
7a, the gene expression pattern of the combination group was more similar to that of the WT group and more distinct from that of the control group than those of the single-natural product groups
