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Mitochondrial metabolism and KRASMAPK axis in CRC chemoresistance Although chemotherapeutic agents such as 5-FU, oxaliplatin, and irinotecan remain central to CRC treatment, the metabolic adaptability of tumor cells continues to undermine their long-term efficacy [23]

[DOI] [PMC free article] [PubMed] [Google Scholar] Chen Y, Shertzer HG, Schneider SN, Nebert DW, Dalton TP

HATs add chromatin acetyl groups, make chromatin conformation more relaxed, and promote gene transcription, whereas HDACs act in reverse ways

These polysaccharides stimulate the growth of healthy bacteria and suppress harmful bacteria. Unlike other foods, which break down with stomach acid, the polysaccharides in mushrooms pass through the gut to the colon, encouraging good bacteria to grow along the way