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3.1.2 Mechanism of lipid peroxidation-mediated ferroptosis involved in ischemic stroke As outlined, lipid peroxidation, particularly the conversion of PUFAs in the phospholipid bilayer to L-OOHs, is a crucial mechanism of ferroptosis and plays a significant role in the development of IS

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Ferroptosis in fibroblasts During wound healing, fibroblasts are responsible for synthesizing ECM and promoting repair

Ethics declarations Ethics approval and consent to participate This study received approval from the Institutional Review Board (IRB) of the Federal University of Minas Gerais (UFMG) (CAAE3768820.1.0000.5149)