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In the future, it will be of interest to further assess the therapeutic benefit of GSH precursor supplementation with Immunocal in additional preclinical animal models of neurodegeneration and ultimately in clinical trials of patients afflicted with neurodegenerative disorders

To cope with the elevated oxidative stress they generate, cancer cells enhance their antioxidant capacity, largely through sustained activation of the transcription factor NRF2 often driven by mutations in its negative regulator KEAP1

A phenotype marked by chronic inflammation, gut dysfunction, and systemic inflammatory markers may benefit from anti-inflammatory support

Expression of 341 highly transcribed genes was slightly enhanced in Pmc4-depleted cells (Supplementary Fig