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Key points: Formulation: Most commonly, cyanocobalamin or hydroxocobalamin in aqueous solution is used

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In short-term, placebo-controlled trials, patients who had received treatment with STS had a mean weight loss of 1.2 lb compared to a gain of 0.3 lb in patients who had received the placebo patch.55 A total of 2.1% of patients treated with STS and 2.4% of patients on placebo experienced a clinically significant ( 5%) weight gain during therapy
