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Description
Manipulation of B-cell responses with histone deacetylase inhibitors

The vast majority of these trials used intra-articular injections of mesenchymal stem cells and reported statistically significant improvements in patient-reported pain and function

Among FDA-approved ADCs, commonly utilized payloads include: derivative of auristatin (MMAE), derivatives of maytansinoid (DM1 and DM4), derivatives of camptothecin (SN-38 and DXd) and DNA alkylators (calicheamicin and PBD) [221, 222]

But they align with the robust preclinical data showing TA1's ability to modulate, rather than suppress, immune system function
