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+ Glucose-6-phosphate dehydrogenase Glucose-6-phosphate dehydrogenase ( G6PD or G6PDH ) (EC 1.1.1.49) is a cytosolic enzyme that catalyzes the chemical reaction: [1] This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the reduced form of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH)

Curran CS, Kopp JB (2023) The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease

141 It is critical for maintaining protein homeostasis (proteostasis)

Dris, R., Gasperi, J., Saad, M., Mirande, C