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Arsenic impairs DNA repair, induces oxidative stress, and reprograms epigenetic regulation, collectively weakening genomic stability [210]

10.1016/j.cbi.2014.10.016 36 LushchakV

The active form, 1,25-dihydroxyvitamin D3 (1,25[OH] 2 D 3 ), binds to the vitamin D receptor (VDR) expressed in endometrial stromal cells, leading to suppression of pro-inflammatory cytokine production (e.g., IL-8, TNF-), inhibition of NF-B signaling, and reduction in prostaglandin synthesis, which collectively dampen the chronic inflammatory milieu characteristic of endometriosis [20,21,22,23]

Screening is crucial for early detection, when cure rates exceed 90%
