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Hair cycle arrest occurs in the Pomeranian, Schipperke, Malamute, Samoyed, Chow Chow, Keeshound, and miniature and toy poodle

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Ammonia readily crosses the blood-brain barrier and is thought to inhibit glutamate uptake, thereby increasing extracellular glutamate concentrations in the brain and resulting in activation of NMDA receptors

Mitochondria are the main producer of reactive oxygen species (ROS) and free oxygen radicals, which include ozone (O 3 ), singlet oxygen ( 1 O 2 ), superoxide radical anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical (HO ), which are extremely chemically reactive and can react with virtually all substances in the cell [20]