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Curcumin elicits antianxiety and antidepressant-like responses in chronic unpredictable mild stress rats, effectively reversing depressive-like and anxiety-like behaviors, as demonstrated by reduced immobility times in the forced swim test, restored sucrose preference in the sucrose preference test, and increased total distance traveled in the open field test

D., Pfeiffer, B., Abbenante, G

Additionally, CuSAE also exhibits peroxidase (POD)- and glutathione oxidase (GSHOx)-mimicking activities, which elevate oxidative stress in tumor cells, thereby blocking the compensatory repair mechanisms and continuously activating tumor disulfidptosis

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