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In this model, excess ROS plays a role in decreasing the expression of PKC II, as overexpression of GPx1 increases PKC II expression and ERK1/2 activation

Biomarker guidance (Prx redox state, GSH/GSSG, LIP assays, cysteine-oxidation proteomics, compartment-targeted reporters) helps titrate dose, route and timing, minimizing off-target effects and avoiding the common pitfall of trading one pathology for another by over-suppressing beneficial stress responses (Murphy et al

CA Cancer J Clin 71(1):733 Vessella RL, Corey E (2006) Targeting factors involved in bone remodeling as treatment strategies in prostate cancer bone metastasis

Cohen S, Mikuls TR (2025): Initial pharmacologic management of rheumatoid arthritis in adults