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In this second approach, higher similarity resulted in greater weight and, consequently, greater contribution to taxonomic assignment

It remains a research compound that some clinics and individuals have begun using despite the lack of regulatory approval

Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

One of the commonly reported microbiome differences between obese/HFD-fed animals and lean controls is an increased Firmicutes : Bacteroidetes ratio 43,44