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127 All these studies suggest that inflammatory cytokines play a major role in the production of NGF, BDNF, and neurotrophins, which results in nerve ingrowth into the disc and thus generates discogenic pain

Preclinical studies on NAD+ and cancer are often misinterpreted, and media coverage can exaggerate preliminary or unrelated findings, creating confusion

Emerging evidence demonstrates that the dynamic modification of histones through methylation/demethylation can link metabolism with transcription, acting as molecular transducers of metabolic signals to chromatin

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