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As the principal products of dietary fiber fermented by intestinal microbiota, SCFAs such as acetic, propionic, and butyric acids can provide energy to enterocytes and promote intestinal barrier integrity (51)

Its design objective was specific: to produce a GHRP-class compound that drove GH release with potency comparable to GHRP-6 but without the off-target cortisol and prolactin effects that complicated the use of earlier compounds in selective ghrelin-receptor research

Also, the hypertrophic response induced by mechanical-overload is fully preserved in muscles from transgenic mice that expresses a dominant negative IGF-I receptor specifically in skeletal muscle[6]

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