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Consequently, these cells are potentially susceptible to iron toxicity if ferrous iron (Fe) levels were to be elevated rapidly and react with ROS via the Fenton reaction to cause ferroptosis
The immunoconjugate of claim 23, wherein said antibody is attached to a cytotoxin
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Supplementation of autophagy inhibitor 3-methyladenine (3-MA) could reverse the damage caused by inhibiting TIGAR gene, indicating that the decrease of autophagy activation is related to the neuroprotective effect of TIGAR
