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This phenomenon, sometimes referred to as early worsening of diabetic retinopathy, appears to be related to the magnitude and speed of glucose lowering rather than a direct effect of the medication

Experimental Neurology 2011

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2.3 Fatigue score measurement During the clinical visits, the treating physician recorded the fatigue level using Question 1 adapted from the Bristol rheumatoid arthritis fatigue numerical rating scale (BRAF-NRS) ( i.e
