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In intestinal epithelial cells of DSS-induced colitis mice, downregulation of the Nrf2-GPx4 signaling pathway promotes ferroptosis, while Furin protease can inhibit ferroptosis and protect intestinal epithelial cells by activating the Nrf2-GPx4 signaling pathway [282, 283]

10.1007/978-3-319-66682-2_9 Glutathione in Plant Growth, Development, and Stress Tolerance 24 ChronopoulouE.GeorgakisN.Nianiou-ObeidatI.MadesisP.PerperopoulouF.PouliouF.et al (2017b)

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