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These criteria include appropriate affinity for the target antigen, minimal or absent binding to off-target sites, and the ability to efficiently penetrate and internalize within tumor cells [44]

However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

[PubMed: 12376586] 57

Juntendo Med J
