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The gut microbiome further modulates MRIS progression via metabolites like trimethylamine N -oxide (TMAO), influencing platelet reactivity [13]

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30 , 31 Since ()-huperzine A (1) inhibits AChE 50-fold more efficiently than the (+)-enantiomer ent -1, the relationship between absolute stereochemistry and attenuation of A toxicity has been studied